Though Greybane manages to chase off Gwenn, Dwight is shot in the process and Karen is understandably distraught. Upon Greybane's suggestion she heads off with him, Nick and an injured Dragoon. Settling in an abandoned house she explains some of her backstory to Greybane.
Later she is shown burying her grandfather, along with Greybane and Nick. After Greybane explains his plan she objects, eventually convincing him to take her along to face the Dragoons.
While heading to Limeridge the group stop off to let Greybane gather supplies. While Karen talks to Nick, the Dragoon makes off with their supplies. Upon Greybane's return the group agree to go to the port of Brookfield to scavenge more supplies.
Little has been shown of Karen. Though she appears to be a rather caring individual.
Karen is just a normal human.